What is oxidized in the Krebs cycle?

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Multiple Choice

What is oxidized in the Krebs cycle?

Explanation:
Oxidation in the Krebs cycle means removing electrons with the help of dehydrogenases, producing NADH or FADH2. The first oxidative step converts isocitrate to α-ketoglutarate, carried out by isocitrate dehydrogenase, with CO2 released and NADH formed. Later in the cycle, malate is oxidized to oxaloacetate by malate dehydrogenase, also producing NADH. Citrate is formed from acetyl-CoA and oxaloacetate and is not oxidized itself during the cycle. So, the molecule that undergoes oxidation in the Krebs cycle is isocitrate (and malate is oxidized later in the cycle).

Oxidation in the Krebs cycle means removing electrons with the help of dehydrogenases, producing NADH or FADH2. The first oxidative step converts isocitrate to α-ketoglutarate, carried out by isocitrate dehydrogenase, with CO2 released and NADH formed. Later in the cycle, malate is oxidized to oxaloacetate by malate dehydrogenase, also producing NADH. Citrate is formed from acetyl-CoA and oxaloacetate and is not oxidized itself during the cycle. So, the molecule that undergoes oxidation in the Krebs cycle is isocitrate (and malate is oxidized later in the cycle).

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