MHC class I molecules are present in all nucleated cells and display endogenous antigens to which T cells?

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Study for the UCF Biomedical Exit Exam. Access flashcards and multiple-choice questions with detailed hints and explanations. Prepare for success!

Multiple Choice

MHC class I molecules are present in all nucleated cells and display endogenous antigens to which T cells?

Explanation:
MHC class I molecules present proteins made inside the cell (endogenous antigens) on nearly all nucleated cells. These peptide–MHC I complexes are recognized by CD8+ cytotoxic T cells through their T-cell receptor, with CD8 acting as a co-receptor. This pairing enables CD8+ T cells to detect infected or abnormal cells and initiate targeted killing. In contrast, MHC class II presents extracellular peptides to CD4+ helper T cells, and NK cells don’t use a T-cell receptor to recognize these peptide–MHC I presentations.

MHC class I molecules present proteins made inside the cell (endogenous antigens) on nearly all nucleated cells. These peptide–MHC I complexes are recognized by CD8+ cytotoxic T cells through their T-cell receptor, with CD8 acting as a co-receptor. This pairing enables CD8+ T cells to detect infected or abnormal cells and initiate targeted killing. In contrast, MHC class II presents extracellular peptides to CD4+ helper T cells, and NK cells don’t use a T-cell receptor to recognize these peptide–MHC I presentations.

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